Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion of MMP-13 protein to the culture supernatant of chondrocytes | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Homo sapiens | - |
chondrocyte | interleukin-1beta-induced, osteoarthritic | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in the chondrocytes pretreated with the JNK inhibitor SP600125, stimulation with interleukin-1beta shows an 88% increase in miR-27b expression and an 14fold increase in MMP-13 mRNA expression compared with controls. Pretreatment of osteoarthritic chondrocytes with the p38 MAPK inhibitor SB202190 suppresses interleukin-1beta-induced MMP-13 mRNA expression by 90% | up |
General Information | Comment | Organism |
---|---|---|
additional information | interleukin-1beta-induced activation of signal transduction pathways associated with the expression of MMP-13 downregulates the expression of miR-27b micro-RNA. Thus, miR-27b may play a role in regulating the expression of MMP-13 in human chondrocytes, with negative regulation of miR-27b expression by activation of NF-kappaB | Homo sapiens |
physiological function | MMPs are important regulators of tissue remodeling and repair | Homo sapiens |